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-synuclein, which is a principal element of Lewy bodies, in PARK one in 1997 and parkin in PARK two in 1998, which is an E3 ubiquitin ligase and will cause endoplasmic reticulum (ER) anxiety, advise that dysfunction of the intracellular proteinase systems, such as ubiquitin-proteasome technique or lysosomal system, which removes unnecessary poisono